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61.
Yael Klin Alexander Zlotnik Matthew Boyko Yoram Shapira 《Biochemical and biophysical research communications》2010,399(4):694-698
Excess l-glutamate (glutamate) levels in brain interstitial and cerebrospinal fluids (ISF and CSF, respectively) are the hallmark of several neurodegenerative conditions such as stroke, traumatic brain injury or amyotrophic lateral sclerosis. Its removal could prevent the glutamate excitotoxicity that causes long-lasting neurological deficits. As in previous studies, we have established the role of blood glutamate levels in brain neuroprotection, we have now investigated the contribution of the peripheral organs to the homeostasis of glutamate in blood. We have administered naive rats with intravenous injections of either l-[1-14C] Glutamic acid (l-[1-14C] Glu), l-[G-3H] Glutamic acid (l-[G-3H] Glu) or d-[2,3-3H] Aspartic acid (d-[2,3-3H] Asp), a non-metabolized analog of glutamate, and have followed their distribution into peripheral organs. We have observed that the decay of the radioactivity associated with l-[1-14C] Glu and l-[G-3H] Glu was faster than that associated with glutamate non-metabolized analog, d-[2,3-3H] Asp. l-[1-14C] Glu was subjected in blood to a rapid decarboxylation with the loss of 14CO2. The three major sequestrating organs, serving as depots for the eliminated glutamate and/or its metabolites were skeletal muscle, liver and gut, contributing together 92% or 87% of total l-[U-14C] Glu or d-[2,3-3H] Asp radioactivity capture. l-[U-14C] Glu and d-[2,3-3H] Asp showed a different organ sequestration pattern. We conclude that glutamate is rapidly eliminated from the blood into peripheral tissues, mainly in non-metabolized form. The liver plays a central role in glutamate metabolism and serves as an origin for glutamate metabolites that redistribute into skeletal muscle and gut. The findings of this study suggest now that pharmacological manipulations that reduce the liver glutamate release rate or cause a boosting of the skeletal muscle glutamate pumping rate are likely to cause brain neuroprotection. 相似文献
62.
Stephen J. Clark Richard W. Thompson 《Human ecology: an interdisciplinary journal》1987,15(3):289-300
Births in Greene County, Alabama for the years 1980–1984 were examined and an overall seasonal trend was found with a peak from August through November. This trend was found to be most pronounced among women greater than 24 yeas old, and among multiparous women, and to be negatively correlated with seasonal variations in temperature and daylight. The phenomenon is likely multifactorial in origin, with sociocultural factors playing a considerable role. The influence of increasing maternal age and parity in the expression of the seasonal trend may be a function of age-related changes in families, with nuclear families acting as the most powerful potentiators of seasonality. 相似文献
63.
A. A. Savage 《Hydrobiologia》1986,133(1):3-19
Oak Mere, the water body studied, is a moderately productive base-poor lowland lake. It has zones of submerged marginal vegetation
growing on sand at the south-west end and on peat at the north-east end. The distributions of L. vespertina and other macroinvertebrates are described in relation to these two distinct areas. Laboratory experiments on behaviour and
survival are described in an attempt to explain the patterns of distribution. The seasonal distribution, variations in population
density, spatial distribution variance in relation to mean density, life cycle, length-weight relationship, growth and biomass
of L. vespertina are then described during two years at the sandy south-west end. The data are used to estimate annual production. Distribution,
life cycle, growth and production are compared with populations in water bodies of lower conductivity in the British Isles
and Scandinavia. 相似文献
64.
Andrés Baselga Jorge M. Lobo Jens‐Christian Svenning Miguel B. Araújo 《Journal of Biogeography》2012,39(4):760-771
Aim Do species range shapes follow general patterns? If so, what mechanisms underlie those patterns? We show for 11,582 species from a variety of taxa across the world that most species have similar latitudinal and longitudinal ranges. We then seek to disentangle the roles of climate, extrinsic dispersal limitation (e.g. barriers) and intrinsic dispersal limitation (reflecting a species’ ability to disperse) as constraints of species range shape. We also assess the relationship between range size and shape. Location Global. Methods Range shape patterns were measured as the slope of the regression of latitudinal species ranges against longitudinal ranges for each taxon and continent, and as the coefficient of determination measuring the degree of scattering of species ranges from the 1:1 line (i.e. latitudinal range = longitudinal range). Two major competing hypotheses explaining species distributions (i.e. dispersal or climatic determinism) were explored. To this end, we compared the observed slopes and coefficients of determination with those predicted by a climatic null model that estimates the potential range shapes in the absence of dispersal limitation. The predictions compared were that species distribution shapes are determined purely by (1) intrinsic dispersal limitation, (2) extrinsic dispersal limitations such as topographic barriers, and (3) climate. Results Using this methodology, we show for a wide variety of taxa across the globe that species generally have very similar latitudinal and longitudinal ranges. However, neither neutral models assuming random but spatially constrained dispersal, nor models assuming climatic control of species distributions describe range shapes adequately. The empirical relationship between the latitudinal and longitudinal ranges of species falls between the predictions of these competing models. Main conclusions We propose that this pattern arises from the combined effect of macroclimate and intrinsic dispersal limitation, the latter being the major determinant among restricted‐range species. Hence, accurately projecting the impact of climate change onto species ranges will require a solid understanding of how climate and dispersal jointly control species ranges. 相似文献
65.
A preliminary analysis of distribution patterns in a large, pantropical genus, Barleria L. (Acanthaceae) 总被引:1,自引:0,他引:1
Barleria L. (Acanthaceae) is a large, polymorphic, widespread genus of herbs and shrubs comprising about 300 species, occurring mainly in Africa and Asia but with one species, Barleria oenotheroides Dum.Cours., extending to the New World tropics. Recent completion of a monographic infra-generic classification of the genus (in which seven sections are recognised, and the names of four of these validated in this paper—see Appendix 1), has facilitated a comprehensive analysis of distribution patterns on a global scale. The richest representation of Barleria is in Africa where there are two centres of diversity, one in tropical East Africa (about eighty species) and the other in southern Africa (about seventy species). The number of species tails off rapidly to both the Far East and the West. Barleria shows a marked trans-Atlantic disjunction between West Africa and the Neotropics, with B. oenotheroides shared by these two regions. This type of disjunction, which is known in other genera of the family, cannot be adequately explained in Barleria on the basis of long-distance dispersal or past continental movements. There is a high degree of regional endemism (e.g. 75% for the Indian subcontinent) at both the species and sectional levels within this genus. The degree of similarity between regions is correspondingly low. The endemics in each region tend to belong to only one or a few of the sections. There are few truly widespread taxa within the genus. East and West Africa are the only regions in which all sections are represented. Sections Barleria and Prionitis C.B. Cl. are the most widespread in the genus; Sections Somalia (Oliv.) Lindau, Fissimura M. Balkwill and Stellatohirtae M. Balkwill are mainly restricted to Africa and Sections Chrysothrix M. Balkwill and Cavirostrata M. Balkwill are the most restricted, occurring mainly in India and Sri Lanka. On a local scale, many of the species show highly restricted, clumped distributions; this is apparently related to particular soil types and possibly to the short-distance, ballistic mode of seed dispersal. This account of the biogeography of Barleria is to be regarded as preliminary, as much taxonomic work at the species level remains to be done before a full-scale cladistic biogeographic account can be undertaken. Particular areas worthy of future investigation include establishing the centre of origin of the genus and investigating the basis for the high degree of endemism shown by many of the species. 相似文献
66.
LARS HEDENÄS 《Botanical journal of the Linnean Society. Linnean Society of London》2008,156(3):341-354
Molecular variation in Antitrichia curtipendula (Hedw.) Brid. s.l. was studied based on the nuclear internal transcribed spacer (ITS) and the chloroplast markers trn L- trn F and rpl 16, and analysed by neighbour joining (for ITS; recombination present), maximum parsimony (chloroplast markers) and TCS (haplotype network). Old World plus E North American populations belong to a different lineage than those of W North America. These are molecularly well differentiated and are treated as A. curtipendula and A. gigantea (Sull. & Lesq.) Kindb. Two distinct groups of Old World haplotypes are separated by one 'missing' haplotype and are interpreted as cryptic species. Tropical African populations share one ITS deletion and form a lineage within one of the cryptic species. Molecular variation within A. gigantea , within each of the two cryptic Old World plus E North American (except tropical African) haplotype groups, and among tropical African populations are of similar magnitude, suggesting that analogous mechanisms and similar time spans explain the found variation. Events related to Pleistocene climatic oscillations are suggested as having caused this differentiation within each group, whereas the African lineage was probably split off before this. Identical tRNA-Gly sequences were found in 33 specimens; new primers were designed for rpl 16 and ITS 1+2. © 2008 The Linnean Society of London, Botanical Journal of the Linnean Society , 2008, 156 , 341–354. 相似文献
67.
Steven I. Higgins Robert B. O’Hara Olga Bykova Michael D. Cramer Isabelle Chuine Eva‐Maria Gerstner Thomas Hickler Xavier Morin Michael R. Kearney Guy F. Midgley Simon Scheiter 《Journal of Biogeography》2012,39(12):2132-2145
Aim To develop a physiologically based model of the plant niche for use in species distribution modelling. Location Europe. Methods We link the Thornley transport resistance (TTR) model with functions which describe how the TTR’s model parameters are influenced by abiotic environmental factors. The TTR model considers how carbon and nutrient uptake, and the allocation of these assimilates, influence growth. We use indirect statistical methods to estimate the model parameters from a high resolution data set on tree distribution for 22 European tree species. Results We infer, from distribution data and abiotic forcing data, the physiological niche dimensions of 22 European tree species. We found that the model fits were reasonable (AUC: 0.79–0.964). The projected distributions were characterized by a false positive rate of 0.19 and a false negative rate 0.12. The fitted models are used to generate projections of the environmental factors that limit the range boundaries of the study species. Main conclusions We show that physiological models can be used to derive physiological niche dimensions from species distribution data. Future work should focus on including prior information on physiological rates into the parameter estimation process. Application of the TTR model to species distribution modelling suggests new avenues for establishing explicit links between distribution and physiology, and for generating hypotheses about how ecophysiological processes influence the distribution of plants. 相似文献
68.
Estimating cladoceran birth rate: use of the egg age distribution to estimate mortality of ovigerous females and eggs 总被引:2,自引:2,他引:0
The birth rate of natural cladoceran populations can change rapidly (during 2–3 days), reflecting rapid changes in their environment. If the egg ratio is calculated on the basis of egg age distribution, the birth rate can be estimated at short sampling intervals (shorter than egg stage duration) by modified Paloheimo's (1974) formula. When female size structure and age of eggs in clutches at the beginning and the end of a sampling interval are known, death rates of ovigerous females and eggs in separate size classes can be determined and incorporated in birth rate estimates. All these methods have been employed using the data on the population of Diaphanosoma brahyurum from the lake Obsterno (North-Western Belarus) in July–August, 1992. The birth rate values computed by the proposed methods and Poloheimo's formula differed significantly in many cases. The accuracy of birth rate estimations from various calculation methods was tested using a computer simulation. The model contains the essential features of cladoceran life history: distinct egg, juvenile and adult stages, development of eggs and reproduction. The population was divided into 25 age classes, each of 1 day duration. Durations of the egg, juvenile and adult stages were set at 3, 6 and 20 days, respectively. The embryogenesis was divided into three egg stages, each of 1 day duration. Survivorship was set from 0.2 up to 1.0 for each age class. The survivorship and brood size were changed through each of five time intervals (days) that allowed to simulate an increase or reduction of population density. Fecundity, survivorship and egg stage duration remained constant during each of 5 days that assumed stability of an environment (this does not occur in nature). Nevertheless, the egg ratio, proportion of juveniles and birth rates were variable even under these circumstances. Computer simulations showed that Poloheimo's formula evaluates birth rate with the relative error of 62% and usually overestimates its values. We propose methods to decrease errors of birth rate estimations by 3.5–5.5 times. 相似文献
69.
Tardrabassus pakneunensis, n. gen. & sp. is described and illustrated. The new genus shows morphological affinities to three leafhopper subfamilies, Tartessinae, Deltocephalinae, and Iassinae, but is tentatively placed in Iassinae based on the position of the ocelli, the reduced lateral frontal sutures, the leg chaetotaxy, and the structure of the male genitalia. 相似文献
70.